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Sympathetic activity mediates extra-medullary erythropoiesis in the pr…

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작성자 관리자 댓글 0건 조회 2,024회 작성일 22-05-25 16:29

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Sympathetic activity mediates extra-medullary erythropoiesis in the primo vascular system of heart failure rats


Abstract    
The primo-vascular system (PVS) is a newly identified vascular tissue composed of primo-nodes (PNs) and primo-vessels (PVs). Recently we reported that in the heart failure (HF), or hemolytic anemia rats there are similar morphological changes of organ surface (os) PVS associated with extra-medullary erythropoiesis (EME). Exercise training (ExT) is known to induce beneficial effects on HF patients by normalizing the elevated sympathetic tone. However, little is known about whether ExT could also inhibit such HF-induced-morphological changes in the PVS. In this study, we examined (1) the effects of ExT on the morphology of the PVS in the HF rats, and (2) the effects of 6-hydroxydopamine (6-OHDA), a chemical sympathectomy agent on the morphological changes in the PVS of rats with phenylhydrazine-induced hemolytic anemia. HF rats were prepared by ligating the left descending coronary artery. In HF rats, we observed an increase in the size of the PNs (P < 0.01), the number of the osPVS tissue samples per rat (P < 0.05), the proportion of osPVS tissue samples with red chromophore (P < 0.001), and the number of RBCs (P < 0.001) in PN. ExT ameliorated these HF-induced osPVSs changes except the number of samples per rat. Blocking sympathetic activity with 6-OHDA dramatically reduced the number of samples per rat in normal rats. The treatment of 6-OHDA normalized the enlarged PN size (P < 0.05) and the elevated proportion of the tissues with red chromophore (P < 0.001) in the rats with hemolytic anemia. Taken together, the results indicate that the inhibition by ExT and removal by 6-OHDA of sympathetic tone block the erythropoietic morphological changes of the osPVS tissue in the HF and anemia rats, respectively. This study implies that the sympathetic regulation may play important roles in regulation of the morphology and function of the osPVS in the normal and disease states. 

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