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Anemia–Induced Erythropoiesis in Organ Surface Primo Vascular System i…

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작성자 관리자 댓글 0건 조회 2,009회 작성일 22-05-25 16:32

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Anemia–Induced Erythropoiesis in Organ Surface Primo Vascular System in Rats


Abstract    
The primo vascular system (PVS) is a novel circulatory system that has been claimed as the anatomical structure of the acupuncture meridians in early 1960s. The PVS, composed of primo-nodes (PNs) and primo-vessels (PVs), is identified from various animal tissues including the surface of abdominal organ. Previously, we reported that the organ surface PVS (osPVS) tissues are enlarged in the rat model of heart failure and the number of erythrocytes and reticulocytes are significantly increased. These results suggest that an extramedullary erythropoiesis (EMH) occurs in the osPVS of the heart failure rats. However, it is not yet known why such EMH occurs in the osPVS of the heart failure rats. Here, we hypothesized that the EMH in the osPVS is due to the anemic conditions accompanying the heart failure. For this experiment, anemia was induced by injection of phenylhydrazine (PHZ, 40 mg/kg/day, i.p) for 2 days. At day 3 post PHZ injection, the RBC, hematocrit, and hemoglobin were decreased, whereas the reticulocytes, WBC, and MCH were also elevated. All the parameters were trend to recover to normal levels at day 10 post PHZ injection. At day 3 post PHZ injection, the typical milky-colored and semi-transparent osPVS tissue was collected from the surface of internal organs in the peritoneal cavity of rats under a stereomicroscope. The number of sample per rat (p < 0.01) and the mean size of the PN (estimated by the area of photo pictures) are significantly increased, respectively (p < 0.05). In addition, the proportion of osPVS number containing red chromophore was also greater in anemic rats at day 3 (p < 0.001), and recovered to the control level at day 10 post PHZ injection. Taken together, the results show that the ENH occurs at the osPVS in the anemic rats, indicating that the osPVS can function as an EMH tissue. Our results will help to understand the functions of the PVS including the osPVS in normal and disease states. 

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